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Publications of the Bf3R

The scientists of the German Center for the Protection of Laboratory Animals (Bf3R) regularly publish the results of their scientific work in form of peer-reviewed articles in journals or on document servers for preprints, in form of conference publications, as book chapters and patents.

Here you will find a list of Bf3R publications since 2015, sorted by year of publication:

2022:

Bühler, M. & Stolz, A. (2022) Estrogens – Origin of Centrosome Defects in Human cancer? Cells, 11(3), 432. https://doi.org/10.3390/cells11030432

Deng, D. & Zi, Z. (2022). Absolute Quantification of TGF-beta Signaling Proteins Using Quantitative Western Blot. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12. http://dx.doi.org/10.1007/978-1-0716-2277-3_1

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P. & Biebermann, H. (2022). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes, 130 (02), 134-140. http://dx.doi.org/10.1055/a-1522-8535

Heinl, C., Scholman-Végh, A. M. D., Mellor, D., Schönfelder, G., Strech, D., Chamuleau, S. & Bert, B. (2022). Declaration of common standards for the preregistration of animal research – speeding up the scientific progress. PNAS Nexus, pgac016. http://dx.doi.org/10.1093/pnasnexus/pgac016

Jacobs, M. N., Ezendam, J., Hakkert, B., Oelgeschläger, M. & Hakkert, B. (2022). Potential of concentration-response data to broaden regulatory application of in vitro test guidelines. ALTEX - Alternatives to Animal Experimentation. http://dx.doi.org/10.14573/altex.2107091

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2022). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947.http://dx.doi.org/10.1016/j.envint.2021.106947

Kornhuber, M. & Dunst, S. (2022). Automated Classification of Cellular Phenotypes Using Machine Learning in Cellprofiler and CellProfiler Analyst. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12. http://dx.doi.org/10.1007/978-1-0716-2277-3_14

Körber, N. (2022). MIA: An Open Source Standalone Deep Learning Application for Microscopic Image Analysis. bioRxiv, 1-12. http://dx.doi.org/10.1101/2022.01.14.476308

Li, Y. & Zi, Z. (2022). Optogenetic Control of TGF-beta Signaling. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 113-124.http://dx.doi.org/10.1007/978-1-0716-2277-3_9

Mihelakis, M., Ndikung, J., Oelgeschläger, M. & Ertych, N. (2022). The 4th dimension of in vitro systems - Time to level up. Environment International, 164, 107256. http://dx.doi.org/10.1016/j.envint.2022.107256

Renko, K., Kerp, H., Pape, J., Rijntjes, E., Burgdorf, T., Führer, D. & Köhrle, J. (2022). Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis. Frontiers in Toxicology, 4, 822993. http://dx.doi.org/10.3389/ftox.2022.822993

Schneider, M. R., Oelgeschläger, M., Burgdorf, T., Meer, P. v., Theunissen, P., Kienhuis, A. S., Piersma, A. H. & Vandebriel, R. J. (2022). Applicability of organ-on-chip systems in toxicology and pharmacology. Critical Reviews in Toxicology, 1-15. http://dx.doi.org/10.1080/10408444.2021.1953439

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbaumer, B. & Segelcke, D. (2022). The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats. Frontiers in Veterinary Science, 9, 841431. http://dx.doi.org/10.3389/fvets.2022.841431

Zi, Z. & Liu, X. (2022). TGF-Beta Signaling. Methods in Molecular Biology, 2488. Humana, New York, NY. http://dx.doi.org/10.1007/978-1-0716-2277-3

2021:

Accuosto, P., Neves, M., & Saggion, H. (2021). Argumentation mining in scientific literature: from computational linguistics to biomedicine. http://repositori.upf.edu/handle/10230/47600

Akonor, P. T., Atter, A., Owusu, M., Ampah, J., Andoh?Odoom, A., Overå, R., Kjellevold, M., Pucher, J. & Kolding, J. (2021). Anchovy powder enrichment in brown rice?based instant cereal: a process optimization study using Response Surface Methodology (RSM). Food Science & Nutrition, 9 (8), 4485-4497. http://dx.doi.org/10.1002/fsn3.2424

Desaulniers, D., Vasseur, P., Jacobs, A., Aguila, M. C., Ertych, N. & Jacobs, M. N. (2021). Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications. International Journal of Molecular Sciences, 22 (20), 10969. http://dx.doi.org/10.3390/ijms222010969

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P., & Biebermann, H. (2021). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes. https://doi.org/10.1055/a-1522-8535

Habedank, A., Kahnau, P. & Lewejohann, L. (2021). Alternate without alternative: neither preference nor learning explains behaviour of C57BL/6J mice in the T-maze. Behaviour, 158 (7), 625-662. http://dx.doi.org/10.1163/1568539X-bja10085

Habedank, A., Urmersbach, B., Kahnau, P., & Lewejohann, L. (2021). O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system. Behavior Research Methods. https://doi.org/10.3758/s13428-021-01593-7

Hobbiesiefken, U., Mieske, P., Lewejohann, L. & Diederich, K. (2021). Evaluation of different types of enrichment their usage and effect on home cage behavior in female mice. PLoS ONE, 16 (12), e0261876. http://dx.doi.org/10.1371/journal.pone.0261876

Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. & Lewejohann, L. (2021). Rating enrichment items by group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. bioRxiv. http://dx.doi.org/10.1101/2021.10.20.465117

Kahnau, P., Guenther, A., Boon, M. N., Terzenbach, J. D., Hanitzsch, E., Lewejohann, L. & Brust, V. (2021). Lifetime Observation of Cognition and Physiological Parameters in Male Mice. frontiers in Behavioral Neuroscience, 15, 709775. http://dx.doi.org/10.3389/fnbeh.2021.709775

Kerp, H., Renko, K., Hönes, G. S., Brix, K., Köhrle, J., Moeller, L. C., & Fuehrer, D. (2021). Age dependent response to T4 overtreatment and recovery on systemic and organ level. Journal of Molecular Endocrinology. https://doi.org/10.1530/JME-21-0109

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2021). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947. http://dx.doi.org/10.1016/j.envint.2021.106947

Kornhuber, M., Dunst, S., Schönfelder, G., & Oelgeschläger, M. (2021). The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells. Environment International, 149, 106411. https://doi.org/10.1016/j.envint.2021.106411

Li, Y., Lee, H., Heo, W. D. & Zi, Z. (2021). Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Advanced Biology, 5 (10), 2101008. http://dx.doi.org/10.1002/adbi.202101008

Lossow, K., Renko, K., Schwarz, M., Kopp, J. F., Schomburg, L., Schwerdtle, T. & Kipp, A. P. (2021). The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice. Nutrients, 13 (11), 3773. http://dx.doi.org/10.3390/nu13113773

Marx-Stoelting, P., Solano, M.L.R., Aoyama, H., Adams R.H., Bal-Price A.,, Buschmann, J., Chahoud, I., Clark, R., Fang, T., Fujiwara, M., Gelinsky, M., Grote, K., Horimoto, M., Bennekou, S.H., Kellner, R., Kuwagata, M., Leist, M., Lang, A., Li, W., Mantovani, A., Makris, S.L., Paumgartten, F., Perron, M., Sachana, M., Schmitt, A., Schneider, S., Schönfelder,. G, Schulze, F., Shiota, K., Solecki, R. (2021). 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth. Reprod Toxicol, 100, 155-162. https://doi.org/10.1016/j.reprotox.2020.11.003

Mieske, P., Diederich, K. & Lewejohann, L. (2021). Roaming in a Land of Milk and Honey: Life Trajectories and Metabolic Rate of Female Inbred Mice Living in a Semi Naturalisitc Environment. animals, 11 (10), 3002. http://dx.doi.org/10.3390/ani11103002

Neves, M., & Ševa, J. (2021). An extensive review of tools for manual annotation of documents. Briefings in Bioinformatics, 22(1), 146–163. https://doi.org/10.1093/bib/bbz130

Ohnesorge, N., Heinl, C., & Lewejohann, L. (2021). Current Methods to Investigate Nociception and Pain in Zebrafish. Frontiers in Neuroscience, 15, 632634. https://doi.org/10.3389/fnins.2021.632634

Olevska, A., Bert, B., Ebrahimi, L., Schönfelder, G., & Heinl, C. (2021). Ensuring Reproducible Research Requires a Support Infrastructure: The Value of Public Registries to Publishers. Science Editor, 4–7. https://doi.org/10.36591/SE-D-4401-4

Schmerbeck, S., Schulze, F., Scheinpflug, J., Ebrahimi, L. (2021). Organ-on-chip systems and the 3Rs. Science in School, 54, 1-4. https://www.scienceinschool.org/article/2021/organ-on-chip/

Schneider, M. R. (2021). Losing fat through the skin. Science (New York, N.Y.), 373(6554), 487–488. https://doi.org/10.1126/science.abg9079

Schneider, M. R., Oelgeschläger, M., Burgdorf, T., van Meer, P., Theunissen, P., Kienhuis, A. S., Persma. A. H., Vandebriel, R. J. (2021). Applicability of organ-on-chip systems in toxicology and pharmacology. Crit Rev Toxicol, 1-15.  https://doi.org/10.1080/10408444.2021.1953439

Schönfelder, G., Oelgeschläger, M., Bischoff, P., Kornhuber, M., Dunst, S. & Vogl, S. (2021). Screening Method for Estrogenic and Anti-Estrogenic Activity. Patent Application Publication. https://scholar.google.com/citations?view_op=view_citation&hl=de&user=vdN9E_oAAAAJ&sortby=pubdate&citation  _for_view=vdN9E_oAAAAJ:5Ul4iDaHHb8C

Schwedhelm, P., Kusnick, J., Heinl, C., Schönfelder, G., Bert, B. (2021). How many animals are used for SARS-CoV-2 research? EMBO reports, e53751. https://doi.org.10.15252/embr.202153751

Stevens, C., Hawkins, P., Smulders, T. V., MacLellan, A., Lewejohann, L., Jirkof, P., Boxall, J., Murphy, H., Moody, C. M., Turner, P. V., Makowska, J. I. & Inman, C. (2021). Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting. Animal Technology and Welfare. https://journal.atwjournal.com/atwapril2021#page=7

Sun, Q., Mehl, S., Renko, K., Seemann, P., Görlich, C. L., Hackler, J., Minich, W. B., Kahaly, G. J. & Schomburg, L. (2021). Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis. International Journal of Molecular Sciences, 22 (23), 13088. http://dx.doi.org/10.3390/ijms222313088

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbäumer, B. & Segelcke, D. (2021). The "WWHow" concept for prospective categorization of post-operative severity assessment in rodents. ResearchGate. http://dx.doi.org/10.13140/RG.2.2.14852.86408

Tralau, T., Oelgeschläger, M., Kugler, J., Bloch, D., Braeuning, A., Burgdorf, T., Marx-Stoelting, P., Ritz, V., Schmeisser, S., Trubiroha, A., Zellmer, S., Luch, A., Schönfelder, G., Solecki, R., & Hensel, A. (2021). A prospective whole-mixture approach to assess risk of the food and chemical exposome. Nature Food, 2(7), 463–468. https://doi.org/10.1038/s43016-021-00316-7

Van der Mierden, S., Leenaars, C. H. C., Boyle, E. C., Ripoli, F. L., Gass, P., Durst, M., Goerlich-Jansson, V. C., Jirkof, P., Keubler, L. M., Talbot, S. R., Habedank, A., Lewejohann, L., Tolba, R. H., & Bleich, A. (2021). Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database. ALTEX, 38(1), 111–122. https://doi.org/10.14573/altex.2004221

Voß, A. L., Heuwieser, W., Mee, J. F. & Fischer-Tenhagen, C. (2021). Calving Management: A Questionnaire Survey of Veterinary Subject Matter Experts and Non-Experts. animals, 11 (11), 3129. http://dx.doi.org/10.3390/ani11113129

Wessels, L., Reich, F., Schmoger, S., Pucher, J., Atter, A., Käsbohrer, A., & Hammerl, J. A. (2021). Draft Genome Sequences of Pseudomonas sp. Isolates Recovered from Ghanaian Fish Food Samples in 2018. Microbiology Resource Announcements, 10(6). https://doi.org/10.1128/MRA.01332-20

2020:

Andresen, N., Wöllhaf, M., Hohlbaum, K., Lewejohann, L., Hellwich, O., Thöne-Reineke, C., & Belik, V. (2020). Towards a fully automated surveillance of well-being status in laboratory mice using deep learning: Starting with facial expression analysis. PloS One, 15(4), e0228059. https://doi.org/10.1371/journal.pone.0228059

Ban, Z., Knöspel, F., & Schneider, M. R. (2020). Shedding light into the black box: Advances in in vitro systems for studying implantation. Developmental Biology, 463(1), 1–10. https://doi.org/10.1016/j.ydbio.2020.04.003

Bawden, R., Nunzio, G. D., Grozea, C., Unanue, I., Yepes, A., Mah, N., Martinez, D., Névéol, A., Neves, M., Oronoz, M., Viñaspre, O. P. de, Piccardi, M., Roller, R., Siu, A., Thomas, P., Vezzani, F., Navarro, M., Wiemann, D., & Yeganova, L. (2020). Findings of the WMT 2020 Biomedical Translation Shared Task: Basque, Italian and Russian as New Additional Languages. 5th Conference on Machine Translation. https://hal.inria.fr/hal-02986356

Bischoff, P., Kornhuber, M., Dunst, S., Zell, J., Fauler, B., Mielke, T., Taubenberger, A. V., Guck, J., Oelgeschläger, M., & Schönfelder, G. (2020). Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin. IScience, 23(11), 101683. https://doi.org/10.1016/j.isci.2020.101683

Burow, E., Grobbel, M., Tenhagen, B.-A., Simoneit, C., Szabó, I., Wendt, D., Kürbis, C., Ladwig-Wiegard, M., Banneke, S., & Käsbohrer, A. (2020). Antibiotic Resistance in Escherichia coli from Broiler Chickens After Amoxicillin Treatment in an Experimental Environment. Microbial Drug Resistance (Larchmont, N.Y.), 26(9), 1098–1107. https://doi.org/10.1089/mdr.2019.0442

Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., van Steensel, M. A. M., & Paus, R. (2020). Neuroendocrinology and neurobiology of sebaceous glands. Biological Reviews of the Cambridge Philosophical Society, 95(3), 592–624. https://doi.org/10.1111/brv.12579

Heinl, C., Chmielewska, J., Olevska, A., Grune, B., Schönfelder, G., & Bert, B. (2020). Rethinking the incentive system in science: animal study registries: Preregistering experiments using animals could greatly improve transparency and reliability of biomedical studies and improve animal welfare. EMBO Reports, 21(1), e49709. https://doi.org/10.15252/embr.201949709

Jacobs, M. N., Colacci, A., Corvi, R., Vaccari, M., Aguila, M. C., Corvaro, M., Delrue, N., Desaulniers, D., Ertych, N., Jacobs, A., Luijten, M., Madia, F., Nishikawa, A., Ogawa, K., Ohmori, K., Paparella, M., Sharma, A. K., & Vasseur, P. (2020). Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens. Archives of Toxicology, 94(8), 2899–2923. https://doi.org/10.1007/s00204-020-02784-5

Kahnau, P., Habedank, A., Diederich, K., & Lewejohann, L. (2020). Behavioral Methods for Severity Assessment. Animals, 10(7). https://doi.org/10.3390/ani10071136

Leenaars, C. H. C., van der Mierden, S., Durst, M., Goerlich-Jansson, V. C., Ripoli, F. L., Keubler, L. M., Talbot, S. R., Boyle, E., Habedank, A., Jirkof, P., Lewejohann, L., Gass, P., Tolba, R., & Bleich, A. (2020). Measurement of corticosterone in mice: a protocol for a mapping review. Laboratory Animals, 54(1), 26–32. https://doi.org/10.1177/0023677219868499

Lewejohann, L., Grune, B., Schönfelder, G., & Bert, B. (2020). Cut back on surplus laboratory animals. Nature, 578(7796), 515. https://doi.org/10.1038/d41586-020-00517-3

Lewejohann, L., Schwabe, K., Häger, C., & Jirkof, P. (2020). Impulse for animal welfare outside the experiment. Laboratory Animals, 54(2), 150–158. https://doi.org/10.1177/0023677219891754

Mei, J., Kohler, J., Winter, Y., Spies, C., Endres, M., Banneke, S., & Emmrich, J. V. (2020). Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice. Behavioural Brain Research, 381, 112352. https://doi.org/10.1016/j.bbr.2019.112352

Ndikung, J., Storm, D., Violet, N., Kramer, A., Schönfelder, G., Ertych, N., & Oelgeschläger, M. (2020). Restoring circadian synchrony in vitro facilitates physiological responses to environmental chemicals. Environment International, 134, 105265. https://doi.org/10.1016/j.envint.2019.105265

Névéol, A., Jimeno Yepes, A., & Neves, M. L. (2020). MEDLINE as a parallel corpus: a survey to gain insight on French-, Spanish- and Portuguese-speaking authors’ abstract writing practice. In ELRA (Ed.), International Conference on Language Resources and Evaluation. https://hal.archives-ouvertes.fr/hal-03023950

Neves, M. (2020). Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods. Genomics & Informatics, 18(2), e18. https://doi.org/10.5808/GI.2020.18.2.e18

Neves, M., & Seva, J. (2020). Annotationsaurus: A Searchable Directory of Annotation Tools. ArXiv:2010.06251 [Cs]. http://arxiv.org/abs/2010.06251

Rudeck, J., Vogl, S., Banneke, S., Schönfelder, G., & Lewejohann, L. (2020). Repeatability analysis improves the reliability of behavioral data. PloS One, 15(4), e0230900. https://doi.org/10.1371/journal.pone.0230900

Rudeck, J., Vogl, S., Heinl, C., Steinfath, M., Fritzwanker, S., Kliewer, A., Schulz, S., Schönfelder, G., & Bert, B. (2020). Analgesic treatment with buprenorphine should be adapted to the mouse strain. Pharmacology, Biochemistry, and Behavior, 191, 172877. https://doi.org/10.1016/j.pbb.2020.172877

Stolz, A., Becker, M., Wistorf, E., & Ertych, N. (2020). Biomedical Research Meets Toxicology: How In Vitro Chromosome Instability Methods Can Contribute to Carcinogenicity Prediction. Cancer Research, 80(8), 1626–1629. https://doi.org/10.1158/0008-5472.CAN-19-2822

van Jaarsveld, M. T. M., Deng, D., Ordoñez-Rueda, D., Paulsen, M., Wiemer, E. A. C., & Zi, Z. (2020). Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest. Oncogenesis, 9(3), 35. https://doi.org/10.1038/s41389-020-0219-y

Weegh, N., Füner, J., Janke, O., Winter, Y., Jung, C., Struve, B., Wassermann, L., Lewejohann, L., Bleich, A., & Häger, C. (2020). Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis. Laboratory Animals, 54(1), 63–72. https://doi.org/10.1177/0023677219879455

Wistorf, E., Knöspel, F., Schönfelder, G., & Schneider, M. R. (2020). 3R-related research funding: Insights from a meeting hosted by the German Centre for the Protection of Laboratory Animals (Bf3R). ALTEX, 37(2), 320–323. https://doi.org/10.14573/altex.2002201

Wittkowski, P., Violet, N., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2020). A quantitative medium-throughput assay to measure Caenorhabditis elegans development and reproduction. STAR Protocols, 1(3), 100224. https://doi.org/10.1016/j.xpro.2020.100224

Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020). Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Developmental Cell, 55(6), 784-801.e9. https://doi.org/10.1016/j.devcel.2020.11.007

Zouboulis, C. C., Yoshida, G. J., Wu, Y., Xia, L., & Schneider, M. R. (2020). Sebaceous gland: Milestones of 30-year modelling research dedicated to the “brain of the skin”. Experimental Dermatology, 29(11), 1069–1079. https://doi.org/10.1111/exd.14184

2019:

Bawden, R., Bretonnel Cohen, K., Grozea, C., Jimeno Yepes, A., Kittner, M., Krallinger, M., Mah, N., Neveol, A., Neves, M., Soares, F., Siu, A., Verspoor, K., & Vicente Navarro, M. (2019). Findings of the WMT 2019 Biomedical Translation Shared Task: Evaluation for MEDLINE Abstracts and Biomedical Terminologies. Proceedings of the Fourth Conference on Machine Translation (Volume 3: Shared Task Papers, Day 2), 29–53. https://doi.org/10.18653/v1/W19-5403

Bert, B., Heinl, C., Chmielewska, J., Schwarz, F., Grune, B., Hensel, A., Greiner, M., & Schönfelder, G. (2019). Refining animal research: The Animal Study Registry. PLoS Biology, 17(10), e3000463. https://doi.org/10.1371/journal.pbio.3000463

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C., & Ezendam, J. (2019). Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution. Toxicology in Vitro, 59, 1–11. https://doi.org/10.1016/j.tiv.2019.03.039

Chmielewska, J., Bert, B., Grune, B., & Schönfelder, G. (2019). Rechtliche Aspekte der Anwendung des pharmakologisch wirksamen Stoffs Tamoxifen bei der konditionellen Genausschaltung im Versuchstier Maus. Natur Und Recht, 41(1), 26–32. https://doi.org/10.1007/s10357-018-3457-4

Dunst, S., & Tomancak, P. (2019). Imaging Flies by Fluorescence Microscopy: Principles, Technologies, and Applications. Genetics, 211(1), 15–34. https://doi.org/10.1534/genetics.118.300227

Heberle, A. M., Razquin Navas, P., Langelaar-Makkinje, M., Kasack, K., Sadik, A., Faessler, E., Hahn, U., Marx-Stoelting, P., Opitz, C. A., Sers, C., Heiland, I., Schäuble, S., & Thedieck, K. (2019). The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Science Alliance, 2(2). https://doi.org/10.26508/lsa.201800257

Jirkof, P., Rudeck, J., & Lewejohann, L. (2019). Assessing Affective State in Laboratory Rodents to Promote Animal Welfare-What Is the Progress in Applied Refinement Research? Animals, 9(12). https://doi.org/10.3390/ani9121026

Kelly, L., Goeuriot, L., Suominen, H., Neves, M., Kanoulas, E., Spijker, R., Azzopardi, L., Li, D., Jimmy, Palotti, J., & Zuccon, G. (2019). CLEF eHealth 2019 Evaluation Lab. In L. Azzopardi, B. Stein, N. Fuhr, P. Mayr, C. Hauff, & D. Hiemstra (Eds.), Advances in Information Retrieval (pp. 267–274). Springer International Publishing. https://doi.org/10.1007/978-3-030-15719-7_36

Kelly, L., Suominen, H., Goeuriot, L., Neves, M., Kanoulas, E., Li, D., Azzopardi, L., Spijker, R., Zuccon, G., Scells, H., & Palotti, J. (2019). Overview of the CLEF eHealth Evaluation Lab 2019. In F. Crestani, M. Braschler, J. Savoy, A. Rauber, H. Müller, D. E. Losada, G. Heinatz Bürki, L. Cappellato, & N. Ferro (Eds.), Experimental IR Meets Multilinguality, Multimodality, and Interaction (pp. 322–339). Springer International Publishing. https://doi.org/10.1007/978-3-030-28577-7_26

Knebel, C., Heise, T., Zanger, U. M., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2019). The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food and Chemical Toxicology, 123, 481–491. https://doi.org/10.1016/j.fct.2018.11.039

Knöspel, F., Ban, Z., Schönfelder, G., & Schneider, M. R. (2019). Next milestone in understanding early life-blastoids mimic embryogenesis in vitro. Biology of Reproduction, 100(1), 11–12. https://doi.org/10.1093/biolre/ioy182

Mei, J., Banneke, S., Lips, J., Kuffner, M. T. C., Hoffmann, C. J., Dirnagl, U., Endres, M., Harms, C., & Emmrich, J. V. (2019). Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition. ALTEX, 36(4), 555–571. https://doi.org/10.14573/altex.1812231

Neves, M., Butzke, D., & Grune, B. (2019). Evaluation of Scientific Elements for Text Similarity in Biomedical Publications. Proceedings of the 6th Workshop on Argument Mining, 124–135. https://doi.org/10.18653/v1/W19-4515

Schulze, F., Schneider, M.R. (2019). Hoffnung oder Humbug? Organ-on-a-chip in der biomedizinischen Forschung und als Alternative zum Tierversuch. Deutsches Tierärzteblatt, 67(10).

Solecki, R., Rauch, M., Gall, A., Buschmann, J., Kellner, R., Kucheryavenko, O., Schmitt, A., Delrue, N., Li, W., Hu, J., Fujiwara, M., Kuwagata, M., Mantovani, A., Makris, S.L., Paumgartten, F., Schönfelder, G., Schneider, S., Vogl, S., Kleinstreuer, N., Schneider, M., Schulze, F., Fritsche, E., Clark, R., Shiota, K., Chahoud, I. (2019) Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol. 89, 124-129. https://doi.org/10.1016/j.reprotox.2019.07.003

Wittkowski, P., Marx-Stoelting, P., Violet, N., Fetz, V., Schwarz, F., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2019). Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study. Environmental Science & Technology, 53(21), 12725–12733. https://doi.org/10.1021/acs.est.9b03266

2018:

Fetz, V., Stauber, R. H., & Knauer, S. K. (2018). Translocation Biosensors-Versatile Tools to Probe Protein Functions in Living Cells. Methods in Molecular Biology (Clifton, N.J.), 1683, 195–210. https://doi.org/10.1007/978-1-4939-7357-6_12

Hilse, K. E., Rupprecht, A., Egerbacher, M., Bardakji, S., Zimmermann, L., Wulczyn, A. E. M. S., & Pohl, E. E. (2018). The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Frontiers in Physiology, 9, 747. https://doi.org/10.3389/fphys.2018.00747

Knebel, C., Kebben, J., Eberini, I., Palazzolo, L., Hammer, H. S., Süssmuth, R. D., Heise, T., Hessel-Pras, S., Lampen, A., Braeuning, A., & Marx-Stoelting, P. (2018). Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand. Archives of Toxicology, 92(12), 3471–3486. https://doi.org/10.1007/s00204-018-2321-x

Knebel, C., Neeb, J., Zahn, E., Schmidt, F., Carazo, A., Holas, O., Pavek, P., Püschel, G. P., Zanger, U. M., Süssmuth, R., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2018). Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. Toxicological Sciences, 163(1), 170–181. https://doi.org/10.1093/toxsci/kfy026

Lang, A., Volkamer, A., Behm, L., Röblitz, S., Ehrig, R., Schneider, M., Geris, L., Wichard, J., & Buttgereit, F. (2018). In silico methods - Computational alternatives to animal testing. ALTEX, 35(1), 124–126. https://doi.org/10.14573/altex.1712031

Mei, J., Riedel, N., Grittner, U., Endres, M., Banneke, S., & Emmrich, J. V. (2018). Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry. Scientific Reports, 8(1), 3526. https://doi.org/10.1038/s41598-018-22020-6

Moussallem, D., Ferreira, T. C., Zampieri, M., Cavalcanti, M. C., Xexéo, G., Neves, M., & Ngomo, A.-C. N. (2018). RDF2PT: Generating Brazilian Portuguese Texts from RDF Data. https://arxiv.org/abs/1802.08150

Neves, M., Butzke, D., Schönfelder, G., & Grune, B. (2018). Bf3R at SemEval-2018 Task 7: Evaluating Two Relation Extraction Tools for Finding Semantic Relations in Biomedical Abstracts. Proceedings of The 12th International Workshop on Semantic Evaluation, 816–820. https://doi.org/10.18653/v1/S18-1130

Neves, M., Jimeno Yepes, A., Névéol, A., Grozea, C., Siu, A., Kittner, M., & Verspoor, K. (2018). Findings of the WMT 2018 Biomedical Translation Shared Task: Evaluation on Medline test sets. Proceedings of the Third Conference on Machine Translation: Shared Task Papers, 324–339. https://doi.org/10.18653/v1/W18-6403

Piersma, A. H., Burgdorf, T., Louekari, K., Desprez, B., Taalman, R., Landsiedel, R., Barroso, J., Rogiers, V., Eskes, C., Oelgeschläger, M., Whelan, M., Braeuning, A., Vinggaard, A. M., Kienhuis, A., van Benthem, J., & Ezendam, J. (2018). Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicology in Vitro, 50, 62–74. https://doi.org/10.1016/j.tiv.2018.02.018

Rudeck, J., Bert, B., Marx-Stoelting, P., Schönfelder, G., & Vogl, S. (2018). Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes. Toxicology, 404–405, 76–85. https://doi.org/10.1016/j.tox.2018.06.001

Salatzki, J., Foryst-Ludwig, A., Bentele, K., Blumrich, A., Smeir, E., Ban, Z., Brix, S., Grune, J., Beyhoff, N., Klopfleisch, R., Dunst, S., Surma, M. A., Klose, C., Rothe, M., Heinzel, F. R., Krannich, A., Kershaw, E. E., Beule, D., Schulze, P. C., … Kintscher, U. (2018). Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS Genetics, 14(1), e1007171. https://doi.org/10.1371/journal.pgen.1007171

Scheinpflug, J., Pfeiffenberger, M., Damerau, A., Schwarz, F., Textor, M., Lang, A., & Schulze, F. (2018). Journey into Bone Models: A Review. Genes, 9(5). https://doi.org/10.3390/genes9050247

Schneider, M. R., & Pincelli, C. (2018). The 3R approach to experimental dermatology. Experimental Dermatology, 27(5), 441–442. https://doi.org/10.1111/exd.13673

Schneider, M. R., & Zouboulis, C. C. (2018). Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. Experimental Dermatology, 27(5), 484–488. https://doi.org/10.1111/exd.13513

Steinfath, M., Vogl, S., Violet, N., Schwarz, F., Mielke, H., Selhorst, T., Greiner, M., & Schönfelder, G. (2018). Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole. PLOS ONE, 13(9), e0202762. https://doi.org/10.1371/journal.pone.0202762

Stolz, A., Schönfelder, G., & Schneider, M. R. (2018). Endocrine Disruptors: Adverse Health Effects Mediated by EGFR? Trends in Endocrinology and Metabolism: TEM, 29(2), 69–71. https://doi.org/10.1016/j.tem.2017.12.003

2017:

Bert, B., Dörendahl, A., Leich, N., Vietze, J., Steinfath, M., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2017). Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research. PLoS Biology, 15(12), e2003217. https://doi.org/10.1371/journal.pbio.2003217

Burgdorf, T., Dunst, S., Ertych, N., Fetz, V., Violet, N., Vogl, S., Schönfelder, G., Schwarz, F., & Oelgeschläger, M. (2017). The AOP Concept: How Novel Technologies Can Support Development of Adverse Outcome Pathways. Applied In Vitro Toxicology, 3(3), 271–277. https://doi.org/10.1089/aivt.2017.0011

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017a). Probleme aus der tierversuchsrechtlichen Praxis: Rechtliche Einordnung der Genotypisierungsmethoden sowie der Zucht immunmodifizierter Tiere. Natur Und Recht, 39(6), 385–392. https://doi.org/10.1007/s10357-017-3190-4

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017b). Rechtliche Probleme der Betäubung von Versuchstieren. Natur Und Recht, 39(8), 538–544. https://doi.org/10.1007/s10357-017-3212-2

Dahlhoff, M., Gaborit, N., Bultmann, S., Leonhardt, H., Yarden, Y., & Schneider, M. R. (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. The FEBS Journal, 284(19), 3339–3349. https://doi.org/10.1111/febs.14196

Herold, S., Krämer, D., Violet, N., & King, R. (2017). Rapid process synthesis supported by a unified modular software framework. Engineering in Life Sciences, 17(11), 1202–1214. https://doi.org/10.1002/elsc.201600020

Kodzius, R., Schulze, F., Gao, X., & Schneider, M. R. (2017). Organ-on-Chip Technology: Current State and Future Developments. Genes, 8(10). https://doi.org/10.3390/genes8100266

Schulze, F., Gao, X., Virzonis, D., Damiati, S., Schneider, M. R., & Kodzius, R. (2017). Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips. Genes, 8(10). https://doi.org/10.3390/genes8100244

Weidner, C., Steinfath, M., Wistorf, E., Oelgeschläger, M., Schneider, M. R., & Schönfelder, G. (2017). A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research. Journal of Visualized Experiments, 126, 55768. https://doi.org/10.3791/55768

2016:

Bert, B., Chmielewska, J., Bergmann, S., Busch, M., Driever, W., Finger?Baier, K., Hößler, J., Köhler, A., Leich, N., Misgeld, T., Nöldner, T., Reiher, A., Schartl, M., Seebach?Sproedt, A., Thumberger, T., Schönfelder, G., & Grune, B. (2016). Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish. The EMBO Journal, 35(11), 1151–1154. https://doi.org/10.15252/embj.201694448

Bert, B., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2016). The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research. EMBO Reports, 17(6), 790–792. https://doi.org/10.15252/embr.201642354

Jungnickel, H., Pund, R., Tentschert, J., Reichardt, P., Laux, P., Harbach, H., & Luch, A. (2016). Time-of-flight secondary ion mass spectrometry (ToF-SIMS)-based analysis and imaging of polyethylene microplastics formation during sea surf simulation. The Science of the Total Environment, 563–564, 261–266. https://doi.org/10.1016/j.scitotenv.2016.04.025

Kugler, J., Kemler, R., Luch, A., & Oelgeschläger, M. (2016). Editor’s Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line. Toxicological Sciences, 152(2), 382–394. https://doi.org/10.1093/toxsci/kfw094

Kugler, J., Luch, A., & Oelgeschläger, M. (2016). Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro? Trends in Pharmacological Sciences, 37(10), 822–830. https://doi.org/10.1016/j.tips.2016.06.009

Raasch, M., Rennert, K., Jahn, T., Gärtner, C., Schönfelder, G., Huber, O., Seiler, A. E. M., & Mosig, A. S. (2016). An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex  development. Biomicrofluidics, 10(4), 044102. https://doi.org/10.1063/1.4955184

Schlechtriem, C., Pucher, J., & Michalski, B. (2016). Dietary burden calculations relating to fish metabolism studies. Journal of the Science of Food and Agriculture, 96(5), 1415–1419. https://doi.org/10.1002/jsfa.7607

Weidner, C., Steinfath, M., Opitz, E., Oelgeschläger, M., & Schönfelder, G. (2016). Defining the optimal animal model for translational research using gene set enrichment analysis. EMBO Molecular Medicine, 8(8), 831–838. https://doi.org/10.15252/emmm.201506025

2015:

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2015). Der “vernünftige Grund” zur Tötung von überzähligen Tieren. Eine klassische Frage des Tierschutzrechts im Kontext der biomedizinischen Forschung. Natur Und Recht, 37(10), 677–682. https://doi.org/10.1007/s10357-015-2903-9

Riebeling, C., Fischer, K., Luch, A., & Seiler, A. E. M. (2015). Classification of reproductive toxicants with diverse mechanisms in the embryonic stem cell test. The Journal of Toxicological Sciences, 40(6), 809–815. https://doi.org/10.2131/jts.40.809

Schönfelder, G. (2015). Laboratory animals: German initiative opens up animal data. Nature, 519(7541), 33. https://doi.org/10.1038/519033d

Schönfelder, G., Grune, B., & Hensel, A. (2015). Animal welfare: Europe’s first “3Rs” governmental centre. Nature, 527(7576), 38. https://doi.org/10.1038/527038e

Smirnova, L., Seiler, A. E. M., & Luch, A. (2015). microRNA Profiling as Tool for Developmental Neurotoxicity Testing (DNT). Current Protocols in Toxicology, 64, 20.9.1-20.9.22. https://doi.org/10.1002/0471140856.tx2009s64

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