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Publications of the Bf3R

The scientists of the German Center for the Protection of Laboratory Animals (Bf3R) regularly publish the results of their scientific work in form of peer-reviewed articles in journals or on document servers for preprints, in form of conference publications, as book chapters and patents.

Here you will find a list of Bf3R publications since 2015, sorted by year of publication:


Bredow, C., Thery, F., Wirth, E. K., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.-P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A. (2024). "ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection." Cardiovascular Research.

Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Heinrich, A., Köhrle, J. and Henning, Y. (2024). "Thyroid hormones are upstream regulators of ecophysiological adaptations to the subterranean habitat." Frontiers in Endocrinology.

Kadic, A., Oles, P., Fischer, B. C., Reetz, A. E., Sylla, B.S., Feiertag, K., Ritz, V., Heise, T., Marx-Stölting, P., Tralau, T., Renko, K. and Solano, M. d. L. M. (2024). "In vitro and in vivo investigation of a thyroid axis-specific interference by triazoles." Scientific Reports.

Neves, M. (preprint).”Detection of fields of applications in biomedical abstracts with the support of argumentation elements.” arXiv.

Wagenaars, F., Cenijn, P., Scholze, M., Frädrich, C., Renko, K., Köhrle, J. and Hamers, T. (Online ahead of print). "Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) facilitated thyroid hormone transport using a modified nonradioactive assay." Toxicology in vitro 96.


SCHEER (Scientific Committee on Health, Environmental and Emerging Risks), Opinion on the Revision of Annexes III and IV of Directive 2010/63/EU on the protection of animals used for scientific purposes regarding accommodation parameters and methods of killing for zebrafish, and accommodation parameters for Passerine birds, adopted on 25 September 2023

Audebert, M., Assmann, A.-S., Azqueta, A., Babica, P., Benfenati, E., Bortoli, S., Bouwman, P., Braeuning, A., Burgdorf, T., Coumoul, X., Debizet, K., Dusinska, M., Ertych, N., Fahrer, J., Fetz, V., Le Hegarat, L., Lopez de Cerain, A., Heusinkveld, H. J., Hogeveen, K., Jacobs, M. N., Luijten, M., Raitano, G., Recoules, C., Runden-Pran, E., Saleh, M., Sovadinova, I., Stampar, M., Thibol, L., Tomkiewicz, C., Vettorazzi, A., Van de Water, B., El Yamani, N., Zegura, B. and Oelgeschläger, M. (2023). New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project. Frontiers in Toxicology 5:1220998.

Brandwein, C., Leenaars, C. H. C., Becker, L., Pfeiffer, N., Iorgu, A.-M., Hahn, M., Vairani, G. A., Lewejohann, L., Bleich, A., Mallien, A. S. and Gass, P. (2023). A systematic mapping review of the evolution of the rat Forced Swim Test: Protocols and outcome parameters. Pharmacological Research 196:106917.

Dolokov, A., Andersen, N., Hohlbaum, K., Thöne-Reineke, C., Lewejohann, L., Hellwich, O. (2023) Upper bound tracker: a multi-animal tracking solution for closed laboratory settings. Scitepress, 4, 945–952.

Engel, A. M., El-Khatib, A. H., Klevenhusen, F., Weiss, M., Aboling, S., Sachse, B., Schäfer, B., Weigel, S., Pieper, R. and Fischer-Tenhagen, C. (2023). Detection of Hypoglycin A and MCPrG Metabolites in the Milk and Urine of Pasture Dairy Cows after Intake of Sycamore Seedlings. Journal of agricultural and food chemistry 71:10751-10760.

Fischer-Tenhagen, C., Bohm, D., Finnah, A., Arlt, S., Schlesinger, S., Borchardt, S., Sutter, F., Tippenhauer, C. M., Heuwieser, W. and Venjakob, P. L. (2023). Residue Concentrations of Cloxacillin in Milk after Intramammary Dry Cow Treatment Considering Dry Period Length. Animals 13(16):2558.

GarridoGamarro, E., Svanevik, C. S., Lundebye, A.-K., Sanden, M., D’Agostino, E., Kjellevold, M., Pincus, L. and Pucher, J. (2023). Challenges in the Implementation of Food Safety and Quality Assurance Systems in Small-Scale Fisheries. Food Quality and Safety, 7, 1-9.

Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Hildebrandt, T. B., Holtze, S., Heinrich, A., Sahm, A., Meci, X., Köhrle, J., Rijntjes, E. and Henning, Y. (2023). Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Scientific Reports 13, 3122.

Hackler, J., Demircan, K., Chillon, T. S., Sun, Q., Geisler, N., Schupp, M., Renko, K., Schomburg, L. (2023) High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression. Redox Biology, 2023 Feb; 59: 102592.

Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. and Lewejohann, L. (2023). Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. PLoS One 18 (1), e0278709.

Kahnau, P., Jaap, A., Diederich, K., Gygax, L., Rudeck, J. and Lewejohann, L. (2023). Determining the value of preferred goods based on consumer demand in a home-cage based test for mice. Behavior Research Methods 55 (2), 751-766.

Kahnau, P., Jaap, A., Urmersbach, B., Diederich, K. and Lewejohann, L. (2022). Development of an IntelliCage-based cognitive bias test for mice. Open Research Europe.

Knipper, A.-D., Göhlich, S., Stingl, K., Ghoreishi, N., Fischer-Tenhagen, C., Bandick, N., Tenhagen, B.-A. and Crease, T. (2023). Longitudinal Study for the Detection and Quantification of Campylobacter spp. in Dairy Cows during Milking and in the Dairy Farm Environment. Foods 12(8).

Koch, F., Pieper, R. and Fischer-Tenhagen, C. (2023). Messung der Körpertemperatur beim Schwein: Können Infrarotthermometer eine Alternative sein?. Tierärztliche Praxis: Ausgabe Großtiere / Nutztiere 51(02):84-92.

Körber, N. (2023) MIA is an open-source standalone deep learning application for microscopic image analysis. Cell Reports Methods, 26 June 2023.

Kühne, B. A., Gutierrez-Vázquez, L., Sánchez Lamelas, E., Guardia-Escote, L., Pla, L., Loreiro, C., VGratacós, E., Barenys, M. and Illa, M. (2023). Lactoferrin/sialic acid prevents adverse effects of intrauterine growth restriction on neurite length: investigations in an in vitro rabbit neurosphere model. Frontiers in Celular Neuroscience 17.

Lang, B., Kahnau, P., Hohlbaum , K., Mieske, P., Andresen, N. P., Boon, M. N., Thöne-Reineke, C., Lewejohann, L. and Diederich, K. (2023). Challenges and advanced concepts for the assessment of learning and memory function in mice. Frontiers in Behavioral Neuroscience 17:1230082.

Li, Y., Deng, D., Höfer, C. T., Kim, J., Heo, W. D., Xu, Q., Liu, X. and Zi, Z. (preprint). Liebig’s law of the minimum in the TGF-β pathway. Nature Structural & Molecular Biology.

Mieske, P., Scheinpflug, J., Yorgan, T. A., Brylka, L., Palme, R., Hobbiesiefken, U., Preikschat, J., Lewejohann, L. and Diederich, K. (2023). Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice. Laboratory Animal Research 39:9.

Mills, D. J., Simmance, F., Byrd, K., Ahern, M., Cohen, P., D’Agostino, E., Fiorella, K., Garrido-Gamarro., E., Gondwe, E., Hicks, C., Kaunda, E., Kjellevold, M., Kolding, J., Levsen, A., Lundebye, A. K., Marinda, P., McNeil, A., Nagoli, J., Nankwenya, B., Nico, G., O’Meara, L., Pincus, L., Pucher, J., J., R., Roscher, M., Sanden, M., Seow, T. K., Svanevik, C., Teoh, S. J., Thilsted, S., Tilley, A. and Tuazon, M. A. (2023). Contributions of small-scale fisheries to food security and nutrition. Illuminating Hidden Harvests. 145-174.

Neves, M., Klippert, A., Knöspel, F., Rudeck, J., Stolz, A., Ban, Z., Becker, M., Diederich, K., Grune, B., Kahnau, P., Ohnesorge, N., Pucher, J., Schönfelder, G., Bert, B. and Butzke, D. (2023). Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. Journal of Biomedical Semantics 14(13).

Ramhoj, L., Axelstad, M., Baert, Y., Canas-Portilla, A., Chalmel, F., Dahmen, L., de la Vieja, A., Evrard, B., Haigis, A.C., Hamers, T., Heikamp, K., Holbech, H., Iglesias-Hernandez, P., Knapen, D., Marchandise, L., Morthorst, J.E., Nikolov, N.G., Nissen, A.C.V.E., Oelgeschlaeger, M., Renko, K., Rogiers, V., Schüürmann, G., Stinckens, E., Stub, M.H., Torres-Ruiz, M., Van Duursen, M., Vanhaecke, T., Vergauwen, L., Wedebye, E.B., Svingen, T. (2023) New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project. Frontiers Toxicology, 17 May 2023.

Romero, N. G., Gutierrez, G., Teixido, E., Li, L., Klose, J., Leung, P. C., Cañigueral, S., Fritsche, E. and Barenys, M. (2023). Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: touch-evoked response and light/dark transition. Reproductive Toxicology 121:108469.

Scheinpflug, J., Höfer, C. T., Schmerbeck, S. S., Steinfath, M., Doka, J., Afework Tesfahunegn, Y., Violet, N., Renko, K., Gulich, K., John, T., Schneider, M. R., Wistorf, E., Schönfelder, G., Schulze, F. (2023) A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading. Lab on a Chip, 2023 July 3.

Teixidó, E., Riera-Colomer, C., Raldúa, D., Pubill, D., Escubedo, E., Barenys, M. and López-Arnau, R. (2023). First generation synthetic cathinones produce arrhythmia in zebrafish eleutheroembryos. A New Approach Methodology for New Psychoactive Substances cardiotoxicity evaluation. International Journal of Molecular Sciences.

Uluckan, Ö., Bruno, S., Wang, Y., Wack, N., Wilzopolski, J., Goetschy, J.-F., Delucis-Bronn, C., Urban, B., Fehlmann, D., Stark, H., Hauchard, A., Roussel, E., Kempf, D., Kaupmann, K., Raulf, F., Bäumer, W., Röhn, T. A. and Zerwes, H. G. (2023). Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. European Journal of Pharmacology 945, 175533.

Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G. and Bert, B. (2023). Das Vorliegen eines “vernünftigen Grundes” bei der Tötung überzähliger Versuchstiere. Natur und Recht 45, 225–233.

Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G., Bert, B. (2023) Die Tötung überzähliger Versuchstiere – das Erfordernis des „vernünftigen Grundes“ und die Übertragung aktueller Rechtsprechung auf den Versuchstierbereich. Natur und Recht, Januar 2023, 45, 22-30,

Weber, A.G., Birk, B., Giri, V., Hoffmann, S., Renko, K., Coecke, S., Schneider, S., Funk-Weyer, D., and Landsiedel, R. (2023) Assessment of the Predictivity of DIO1-SK Assay to Investigate DIO1 Inhibition in Human Liver Microsomes. Applied In Vitro Toxicology, Vol. 9, No. 2, 15 June 2023.

Wessels, L., Kjellevold, M., Kolding, J., Odoli, C., Aakre, I., Reich, F. and Pucher, J. (2023). Putting small fish on the table: The underutilized potential of small indigenous fish to improve food and nutrition security in East Africa. Food Security.

Wewetzer, H., Wagenknecht, T., Bert, B. and Schönfelder, G. (2023). The fate of surplus laboratory animals. EMBO Reports 24, :e56551.

Wilhelmi, P., Giri, V., Zickgraf, F. M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R. and Funk-Weyer, D. (2023). A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chemico-Biological Interactions 382.

Wilzopolski, J., Putrianti, E., Balik, P., Goerlich, S., Lindner, T. and Ohnesorge, N. (2023). Assessment of the antinociceptive efficacy of analgesics, anesthetics and other compounds in zebrafish (Danio rerio). Journal of Veterinary Pharmacology and Therapeutics 46(S1):45-45.

Wolter, A., Bucher, C. H., Kurmies, S., Schreiner, V., Konietschke, F., Hohlbaum, K., Klopfleisch, R., Löhning, M., Thöne-Reineke, C., Buttgereit, F., Huwyler, J., Jirkof, P., Rapp, A. E. and Lang, A. (2023). A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports 13 (1), 3824.


Bühler, M., Fahrländer, J., Sauter, A., Becker, M., Wistorf, E., Steinfath, M. and Stolz, A. (2022). GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Science Alliance, 6 (1), e202201499.

Bühler, M. & Stolz, A. (2022) Estrogens – Origin of Centrosome Defects in Human cancer? Cells, 11(3), 432.

Deng, D. & Zi, Z. (2022). Absolute Quantification of TGF-beta Signaling Proteins Using Quantitative Western Blot. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12.

Diederich, K., Schmitt, K., Schwedhelm, P., Bert, B. and Heinl, C. (2022). A guide to open science practices for animal research. PLOS Biology, 20 (9), e3001810.

Engel, A. M., Klevenhusen, F., Moenning, J.-L., Numata, J., Fischer-Tenhagen, C., Sachse, B., Scha?fer, B., Fry, H., Kappenstein, O. and Pieper, R. (2022). Investigations on the Transfer of Quinolizidine Alkaloids from Lupinus angustifolius into the Milk of Dairy Cows. Journal of Agricultural and Food Chemistry, 70 (37), 11749–11758.

 Escher, B. I., Lamoree, M., Antignac, J.-P., Scholze, M., Herzler, M., Hamers, T., Jensen, T. K., Audebert, M., Busquet, F., Maier, D., Oelgeschläger, M., Valente, M. J., Boye, H., Schmeisser, S., Dervilly, G., Piumatti, M., Motteau, S., König, M., Renko, K., Margalef, M., Cariou, R., Ma, Y., Treschow, A. F., Kortenkamp, A. and Vinggaard, A. M. (2022). Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project. International Journal of Environmental Research and Public Health, 19 (20), 12990.

 Fischer-Tenhagen, C., Meier, J. and Pohl, A. (2022). “Do not look at me like that”: Is the facial expression score reliable and accurate to evaluate pain in large domestic animals? A systematic review. Frontiers in Veterinary Science, 9, 1002681.

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P. & Biebermann, H. (2022). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes, 130 (02), 134-140.

Habedank, A., Urmersbach, B., Kahnau, P. and Lewejohann, L. (2022). O mouse, where art thou? The Mouse Position Surveillance System (MoPSS) - an RFID-based tracking system. Behavior Research Methods, 54 (2), 676–689.

Heinl, C., Schönfelder, G. and Bert, B. (2022). Preregistration in Animal Research. In: J. Faintuch and S. Faintuch Integrity of Scientific Research: Fraud, Misconduct and Fake News in the Academic, Medical and Social Environment. 371-378. Springer.

Heinl, C., Scholman-Végh, A. M. D., Mellor, D., Schönfelder, G., Strech, D., Chamuleau, S. & Bert, B. (2022). Declaration of common standards for the preregistration of animal research – speeding up the scientific progress. PNAS Nexus, pgac016.

Jacobs, M. N., Ezendam, J., Hakkert, B., Oelgeschläger, M. & Hakkert, B. (2022). Potential of concentration-response data to broaden regulatory application of in vitro test guidelines. ALTEX - Alternatives to Animal Experimentation.

Kahnau, P., Jaap, A., Hobbiesiefken, U., Mieske, P., Diederich, K., Thöne-Reineke, C., Lewejohann, L. and Hohlbaum, K. (2022). A preliminary survey on the occurrence of barbering in laboratory mice in Germany. Animal Welfare, 31 (4), 433-436.

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2022). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947.

Körber, N. (2022). MIA: An Open Source Standalone Deep Learning Application for Microscopic Image Analysis. bioRxiv.

Kohler, J., Mei, J., Banneke, S., Winter, Y., Endres, M. and Emmrich, J. V. (2022). Assessing spatial learning and memory in mice: Classic radial maze versus a new animal-friendly automated radial maze allowing free access and not requiring food deprivation. Frontiers in Behavioral Neuroscience, 16, 1013624.

Kornhuber, M. & Dunst, S. (2022). Automated Classification of Cellular Phenotypes Using Machine Learning in Cellprofiler and CellProfiler Analyst. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12.

Li, Y. & Zi, Z. (2022). Optogenetic Control of TGF-beta Signaling. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 113-124.

Mackert, O., Wirth, E.K., Sun, R., Winkler, J., Liu, A., Renko, K., Kunz, S., Spranger, J. & Brachs, S. (2022). Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption. Molecular Metabolism, 64: 101563.

Mieske, P., Hobbiesiefken, U., Fischer-Tenhagen, C., Heinl, C., Hohlbaum, K., Kahnau, P., Meier, J., Wilzopolski, J., Butzke, D., Rudeck, J., Lewejohann, L. & Diederich, K. (2022). Bored at home?—A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice, Frontiers in Veterinary Science, 9.

Mihelakis, M., Ndikung, J., Oelgeschläger, M. & Ertych, N. (2022). The 4th dimension of in vitro systems - Time to level up. Environment International, 164, 107256.

Neves, M., Yepes, A. J., Siu, A., Roller, R., Thomas, P., Navarro, M. V., Yeganova, L., Wiemann, D., Di Nunzio, G. M., Vezzani, F., Gerardin, C., Bawden, R., Estrada, D. J., Lima-López, S., Farré-Maduell, E., Krallinger, M., Grozea, C. and Névéol, A. (2022). Findings of the WMT 2022 Biomedical Translation Shared Task: Monolingual Clinical Case Reports. Proceedings of the Seventh Conference on Machine Translation (WMT), 694-723.

Niethammer, M., Burgdorf, T., Wistorf, E., Schönfelder, G. and Kleinsorge, M. (2022). In vitro models of human development and their potential application in developmental toxicity testing. Development, 149 (20), dev200933.

Renko, K., Kerp, H., Pape, J., Rijntjes, E., Burgdorf, T., Führer, D. & Köhrle, J. (2022). Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis. Frontiers in Toxicology, 4, 822993.

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbaumer, B. & Segelcke, D. (2022). The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats. Frontiers in Veterinary Science, 9, 841431.

Weber, A. G., Birk, B., Herrmann, C., Huener, H.-A., Renko, K., Coecke, S., Schneider, S., Funk-Weyer, D. and Landsiedel, R. (2022). A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes. Applied In Vitro Toxicology, 8 (3), 67-82.

Zi, Z. & Liu, X. (2022). TGF-Beta Signaling. Methods in Molecular Biology, 2488. Humana, New York, NY.


Accuosto, P., Neves, M., & Saggion, H. (2021). Argumentation mining in scientific literature: from computational linguistics to biomedicine.

Akonor, P. T., Atter, A., Owusu, M., Ampah, J., Andoh?Odoom, A., Overå, R., Kjellevold, M., Pucher, J. & Kolding, J. (2021). Anchovy powder enrichment in brown rice?based instant cereal: a process optimization study using Response Surface Methodology (RSM). Food Science & Nutrition, 9 (8), 4485-4497.

Desaulniers, D., Vasseur, P., Jacobs, A., Aguila, M. C., Ertych, N. & Jacobs, M. N. (2021). Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications. International Journal of Molecular Sciences, 22 (20), 10969.

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P., & Biebermann, H. (2021). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes.

Habedank, A., Kahnau, P. & Lewejohann, L. (2021). Alternate without alternative: neither preference nor learning explains behaviour of C57BL/6J mice in the T-maze. Behaviour, 158 (7), 625-662.

Habedank, A., Urmersbach, B., Kahnau, P., & Lewejohann, L. (2021). O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system. Behavior Research Methods.

Hobbiesiefken, U., Mieske, P., Lewejohann, L. & Diederich, K. (2021). Evaluation of different types of enrichment their usage and effect on home cage behavior in female mice. PLoS ONE, 16 (12), e0261876.

Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. & Lewejohann, L. (2021). Rating enrichment items by group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. bioRxiv.

Kahnau, P., Guenther, A., Boon, M. N., Terzenbach, J. D., Hanitzsch, E., Lewejohann, L. & Brust, V. (2021). Lifetime Observation of Cognition and Physiological Parameters in Male Mice. frontiers in Behavioral Neuroscience, 15, 709775.

Kerp, H., Renko, K., Hönes, G. S., Brix, K., Köhrle, J., Moeller, L. C., & Fuehrer, D. (2021). Age dependent response to T4 overtreatment and recovery on systemic and organ level. Journal of Molecular Endocrinology.

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2021). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947.

Kornhuber, M., Dunst, S., Schönfelder, G., & Oelgeschläger, M. (2021). The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells. Environment International, 149, 106411.

Li, Y., Lee, H., Heo, W. D. & Zi, Z. (2021). Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Advanced Biology, 5 (10), 2101008.

Lossow, K., Renko, K., Schwarz, M., Kopp, J. F., Schomburg, L., Schwerdtle, T. & Kipp, A. P. (2021). The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice. Nutrients, 13 (11), 3773.

Marx-Stoelting, P., Solano, M.L.R., Aoyama, H., Adams R.H., Bal-Price A.,, Buschmann, J., Chahoud, I., Clark, R., Fang, T., Fujiwara, M., Gelinsky, M., Grote, K., Horimoto, M., Bennekou, S.H., Kellner, R., Kuwagata, M., Leist, M., Lang, A., Li, W., Mantovani, A., Makris, S.L., Paumgartten, F., Perron, M., Sachana, M., Schmitt, A., Schneider, S., Schönfelder,. G, Schulze, F., Shiota, K., Solecki, R. (2021). 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth. Reprod Toxicol, 100, 155-162.

Mieske, P., Diederich, K. & Lewejohann, L. (2021). Roaming in a Land of Milk and Honey: Life Trajectories and Metabolic Rate of Female Inbred Mice Living in a Semi Naturalisitc Environment. animals, 11 (10), 3002.

Neves, M., & Ševa, J. (2021). An extensive review of tools for manual annotation of documents. Briefings in Bioinformatics, 22(1), 146–163.

Ohnesorge, N., Heinl, C., & Lewejohann, L. (2021). Current Methods to Investigate Nociception and Pain in Zebrafish. Frontiers in Neuroscience, 15, 632634.

Olevska, A., Bert, B., Ebrahimi, L., Schönfelder, G., & Heinl, C. (2021). Ensuring Reproducible Research Requires a Support Infrastructure: The Value of Public Registries to Publishers. Science Editor, 4–7.

Schmerbeck, S., Schulze, F., Scheinpflug, J., Ebrahimi, L. (2021). Organ-on-chip systems and the 3Rs. Science in School, 54, 1-4.

Schneider, M. R. (2021). Losing fat through the skin. Science (New York, N.Y.), 373(6554), 487–488.

Schneider, M. R., Oelgeschläger, M., Burgdorf, T., van Meer, P., Theunissen, P., Kienhuis, A. S., Persma. A. H., Vandebriel, R. J. (2021). Applicability of organ-on-chip systems in toxicology and pharmacology. Crit Rev Toxicol, 1-15.

Schönfelder, G., Oelgeschläger, M., Bischoff, P., Kornhuber, M., Dunst, S. & Vogl, S. (2021). Screening Method for Estrogenic and Anti-Estrogenic Activity. Patent Application Publication.  _for_view=vdN9E_oAAAAJ:5Ul4iDaHHb8C

Schwedhelm, P., Kusnick, J., Heinl, C., Schönfelder, G., Bert, B. (2021). How many animals are used for SARS-CoV-2 research? EMBO reports, e53751.

Stevens, C., Hawkins, P., Smulders, T. V., MacLellan, A., Lewejohann, L., Jirkof, P., Boxall, J., Murphy, H., Moody, C. M., Turner, P. V., Makowska, J. I. & Inman, C. (2021). Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting. Animal Technology and Welfare.

Sun, Q., Mehl, S., Renko, K., Seemann, P., Görlich, C. L., Hackler, J., Minich, W. B., Kahaly, G. J. & Schomburg, L. (2021). Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis. International Journal of Molecular Sciences, 22 (23), 13088.

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbäumer, B. & Segelcke, D. (2021). The "WWHow" concept for prospective categorization of post-operative severity assessment in rodents. ResearchGate.

Tralau, T., Oelgeschläger, M., Kugler, J., Bloch, D., Braeuning, A., Burgdorf, T., Marx-Stoelting, P., Ritz, V., Schmeisser, S., Trubiroha, A., Zellmer, S., Luch, A., Schönfelder, G., Solecki, R., & Hensel, A. (2021). A prospective whole-mixture approach to assess risk of the food and chemical exposome. Nature Food, 2(7), 463–468.

Van der Mierden, S., Leenaars, C. H. C., Boyle, E. C., Ripoli, F. L., Gass, P., Durst, M., Goerlich-Jansson, V. C., Jirkof, P., Keubler, L. M., Talbot, S. R., Habedank, A., Lewejohann, L., Tolba, R. H., & Bleich, A. (2021). Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database. ALTEX, 38(1), 111–122.

Voß, A. L., Heuwieser, W., Mee, J. F. & Fischer-Tenhagen, C. (2021). Calving Management: A Questionnaire Survey of Veterinary Subject Matter Experts and Non-Experts. animals, 11 (11), 3129.

Wessels, L., Reich, F., Schmoger, S., Pucher, J., Atter, A., Käsbohrer, A., & Hammerl, J. A. (2021). Draft Genome Sequences of Pseudomonas sp. Isolates Recovered from Ghanaian Fish Food Samples in 2018. Microbiology Resource Announcements, 10(6).


Andresen, N., Wöllhaf, M., Hohlbaum, K., Lewejohann, L., Hellwich, O., Thöne-Reineke, C., & Belik, V. (2020). Towards a fully automated surveillance of well-being status in laboratory mice using deep learning: Starting with facial expression analysis. PloS One, 15(4), e0228059.

Ban, Z., Knöspel, F., & Schneider, M. R. (2020). Shedding light into the black box: Advances in in vitro systems for studying implantation. Developmental Biology, 463(1), 1–10.

Bawden, R., Nunzio, G. D., Grozea, C., Unanue, I., Yepes, A., Mah, N., Martinez, D., Névéol, A., Neves, M., Oronoz, M., Viñaspre, O. P. de, Piccardi, M., Roller, R., Siu, A., Thomas, P., Vezzani, F., Navarro, M., Wiemann, D., & Yeganova, L. (2020). Findings of the WMT 2020 Biomedical Translation Shared Task: Basque, Italian and Russian as New Additional Languages. 5th Conference on Machine Translation.

Bischoff, P., Kornhuber, M., Dunst, S., Zell, J., Fauler, B., Mielke, T., Taubenberger, A. V., Guck, J., Oelgeschläger, M., & Schönfelder, G. (2020). Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin. IScience, 23(11), 101683.

Burow, E., Grobbel, M., Tenhagen, B.-A., Simoneit, C., Szabó, I., Wendt, D., Kürbis, C., Ladwig-Wiegard, M., Banneke, S., & Käsbohrer, A. (2020). Antibiotic Resistance in Escherichia coli from Broiler Chickens After Amoxicillin Treatment in an Experimental Environment. Microbial Drug Resistance (Larchmont, N.Y.), 26(9), 1098–1107.

Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., van Steensel, M. A. M., & Paus, R. (2020). Neuroendocrinology and neurobiology of sebaceous glands. Biological Reviews of the Cambridge Philosophical Society, 95(3), 592–624.

Heinl, C., Chmielewska, J., Olevska, A., Grune, B., Schönfelder, G., & Bert, B. (2020). Rethinking the incentive system in science: animal study registries: Preregistering experiments using animals could greatly improve transparency and reliability of biomedical studies and improve animal welfare. EMBO Reports, 21(1), e49709.

Jacobs, M. N., Colacci, A., Corvi, R., Vaccari, M., Aguila, M. C., Corvaro, M., Delrue, N., Desaulniers, D., Ertych, N., Jacobs, A., Luijten, M., Madia, F., Nishikawa, A., Ogawa, K., Ohmori, K., Paparella, M., Sharma, A. K., & Vasseur, P. (2020). Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens. Archives of Toxicology, 94(8), 2899–2923.

Kahnau, P., Habedank, A., Diederich, K., & Lewejohann, L. (2020). Behavioral Methods for Severity Assessment. Animals, 10(7).

Leenaars, C. H. C., van der Mierden, S., Durst, M., Goerlich-Jansson, V. C., Ripoli, F. L., Keubler, L. M., Talbot, S. R., Boyle, E., Habedank, A., Jirkof, P., Lewejohann, L., Gass, P., Tolba, R., & Bleich, A. (2020). Measurement of corticosterone in mice: a protocol for a mapping review. Laboratory Animals, 54(1), 26–32.

Lewejohann, L., Grune, B., Schönfelder, G., & Bert, B. (2020). Cut back on surplus laboratory animals. Nature, 578(7796), 515.

Lewejohann, L., Schwabe, K., Häger, C., & Jirkof, P. (2020). Impulse for animal welfare outside the experiment. Laboratory Animals, 54(2), 150–158.

Mei, J., Kohler, J., Winter, Y., Spies, C., Endres, M., Banneke, S., & Emmrich, J. V. (2020). Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice. Behavioural Brain Research, 381, 112352.

Ndikung, J., Storm, D., Violet, N., Kramer, A., Schönfelder, G., Ertych, N., & Oelgeschläger, M. (2020). Restoring circadian synchrony in vitro facilitates physiological responses to environmental chemicals. Environment International, 134, 105265.

Névéol, A., Jimeno Yepes, A., & Neves, M. L. (2020). MEDLINE as a parallel corpus: a survey to gain insight on French-, Spanish- and Portuguese-speaking authors’ abstract writing practice. In ELRA (Ed.), International Conference on Language Resources and Evaluation.

Neves, M. (2020). Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods. Genomics & Informatics, 18(2), e18.

Neves, M., & Seva, J. (2020). Annotationsaurus: A Searchable Directory of Annotation Tools. ArXiv:2010.06251 [Cs].

Rudeck, J., Vogl, S., Banneke, S., Schönfelder, G., & Lewejohann, L. (2020). Repeatability analysis improves the reliability of behavioral data. PloS One, 15(4), e0230900.

Rudeck, J., Vogl, S., Heinl, C., Steinfath, M., Fritzwanker, S., Kliewer, A., Schulz, S., Schönfelder, G., & Bert, B. (2020). Analgesic treatment with buprenorphine should be adapted to the mouse strain. Pharmacology, Biochemistry, and Behavior, 191, 172877.

Stolz, A., Becker, M., Wistorf, E., & Ertych, N. (2020). Biomedical Research Meets Toxicology: How In Vitro Chromosome Instability Methods Can Contribute to Carcinogenicity Prediction. Cancer Research, 80(8), 1626–1629.

van Jaarsveld, M. T. M., Deng, D., Ordoñez-Rueda, D., Paulsen, M., Wiemer, E. A. C., & Zi, Z. (2020). Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest. Oncogenesis, 9(3), 35.

Weegh, N., Füner, J., Janke, O., Winter, Y., Jung, C., Struve, B., Wassermann, L., Lewejohann, L., Bleich, A., & Häger, C. (2020). Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis. Laboratory Animals, 54(1), 63–72.

Wistorf, E., Knöspel, F., Schönfelder, G., & Schneider, M. R. (2020). 3R-related research funding: Insights from a meeting hosted by the German Centre for the Protection of Laboratory Animals (Bf3R). ALTEX, 37(2), 320–323.

Wittkowski, P., Violet, N., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2020). A quantitative medium-throughput assay to measure Caenorhabditis elegans development and reproduction. STAR Protocols, 1(3), 100224.

Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020). Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Developmental Cell, 55(6), 784-801.e9.

Zouboulis, C. C., Yoshida, G. J., Wu, Y., Xia, L., & Schneider, M. R. (2020). Sebaceous gland: Milestones of 30-year modelling research dedicated to the “brain of the skin”. Experimental Dermatology, 29(11), 1069–1079.


Bawden, R., Bretonnel Cohen, K., Grozea, C., Jimeno Yepes, A., Kittner, M., Krallinger, M., Mah, N., Neveol, A., Neves, M., Soares, F., Siu, A., Verspoor, K., & Vicente Navarro, M. (2019). Findings of the WMT 2019 Biomedical Translation Shared Task: Evaluation for MEDLINE Abstracts and Biomedical Terminologies. Proceedings of the Fourth Conference on Machine Translation (Volume 3: Shared Task Papers, Day 2), 29–53.

Bert, B., Heinl, C., Chmielewska, J., Schwarz, F., Grune, B., Hensel, A., Greiner, M., & Schönfelder, G. (2019). Refining animal research: The Animal Study Registry. PLoS Biology, 17(10), e3000463.

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C., & Ezendam, J. (2019). Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution. Toxicology in Vitro, 59, 1–11.

Chmielewska, J., Bert, B., Grune, B., & Schönfelder, G. (2019). Rechtliche Aspekte der Anwendung des pharmakologisch wirksamen Stoffs Tamoxifen bei der konditionellen Genausschaltung im Versuchstier Maus. Natur Und Recht, 41(1), 26–32.

Dunst, S., & Tomancak, P. (2019). Imaging Flies by Fluorescence Microscopy: Principles, Technologies, and Applications. Genetics, 211(1), 15–34.

Heberle, A. M., Razquin Navas, P., Langelaar-Makkinje, M., Kasack, K., Sadik, A., Faessler, E., Hahn, U., Marx-Stoelting, P., Opitz, C. A., Sers, C., Heiland, I., Schäuble, S., & Thedieck, K. (2019). The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Science Alliance, 2(2).

Jirkof, P., Rudeck, J., & Lewejohann, L. (2019). Assessing Affective State in Laboratory Rodents to Promote Animal Welfare-What Is the Progress in Applied Refinement Research? Animals, 9(12).

Kelly, L., Goeuriot, L., Suominen, H., Neves, M., Kanoulas, E., Spijker, R., Azzopardi, L., Li, D., Jimmy, Palotti, J., & Zuccon, G. (2019). CLEF eHealth 2019 Evaluation Lab. In L. Azzopardi, B. Stein, N. Fuhr, P. Mayr, C. Hauff, & D. Hiemstra (Eds.), Advances in Information Retrieval (pp. 267–274). Springer International Publishing.

Kelly, L., Suominen, H., Goeuriot, L., Neves, M., Kanoulas, E., Li, D., Azzopardi, L., Spijker, R., Zuccon, G., Scells, H., & Palotti, J. (2019). Overview of the CLEF eHealth Evaluation Lab 2019. In F. Crestani, M. Braschler, J. Savoy, A. Rauber, H. Müller, D. E. Losada, G. Heinatz Bürki, L. Cappellato, & N. Ferro (Eds.), Experimental IR Meets Multilinguality, Multimodality, and Interaction (pp. 322–339). Springer International Publishing.

Knebel, C., Heise, T., Zanger, U. M., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2019). The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food and Chemical Toxicology, 123, 481–491.

Knöspel, F., Ban, Z., Schönfelder, G., & Schneider, M. R. (2019). Next milestone in understanding early life-blastoids mimic embryogenesis in vitro. Biology of Reproduction, 100(1), 11–12.

Mei, J., Banneke, S., Lips, J., Kuffner, M. T. C., Hoffmann, C. J., Dirnagl, U., Endres, M., Harms, C., & Emmrich, J. V. (2019). Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition. ALTEX, 36(4), 555–571.

Neves, M., Butzke, D., & Grune, B. (2019). Evaluation of Scientific Elements for Text Similarity in Biomedical Publications. Proceedings of the 6th Workshop on Argument Mining, 124–135.

Schulze, F., Schneider, M.R. (2019). Hoffnung oder Humbug? Organ-on-a-chip in der biomedizinischen Forschung und als Alternative zum Tierversuch. Deutsches Tierärzteblatt, 67(10).

Solecki, R., Rauch, M., Gall, A., Buschmann, J., Kellner, R., Kucheryavenko, O., Schmitt, A., Delrue, N., Li, W., Hu, J., Fujiwara, M., Kuwagata, M., Mantovani, A., Makris, S.L., Paumgartten, F., Schönfelder, G., Schneider, S., Vogl, S., Kleinstreuer, N., Schneider, M., Schulze, F., Fritsche, E., Clark, R., Shiota, K., Chahoud, I. (2019) Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol. 89, 124-129.

Wittkowski, P., Marx-Stoelting, P., Violet, N., Fetz, V., Schwarz, F., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2019). Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study. Environmental Science & Technology, 53(21), 12725–12733.


Fetz, V., Stauber, R. H., & Knauer, S. K. (2018). Translocation Biosensors-Versatile Tools to Probe Protein Functions in Living Cells. Methods in Molecular Biology (Clifton, N.J.), 1683, 195–210.

Hilse, K. E., Rupprecht, A., Egerbacher, M., Bardakji, S., Zimmermann, L., Wulczyn, A. E. M. S., & Pohl, E. E. (2018). The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Frontiers in Physiology, 9, 747.

Knebel, C., Kebben, J., Eberini, I., Palazzolo, L., Hammer, H. S., Süssmuth, R. D., Heise, T., Hessel-Pras, S., Lampen, A., Braeuning, A., & Marx-Stoelting, P. (2018). Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand. Archives of Toxicology, 92(12), 3471–3486.

Knebel, C., Neeb, J., Zahn, E., Schmidt, F., Carazo, A., Holas, O., Pavek, P., Püschel, G. P., Zanger, U. M., Süssmuth, R., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2018). Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. Toxicological Sciences, 163(1), 170–181.

Lang, A., Volkamer, A., Behm, L., Röblitz, S., Ehrig, R., Schneider, M., Geris, L., Wichard, J., & Buttgereit, F. (2018). In silico methods - Computational alternatives to animal testing. ALTEX, 35(1), 124–126.

Mei, J., Riedel, N., Grittner, U., Endres, M., Banneke, S., & Emmrich, J. V. (2018). Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry. Scientific Reports, 8(1), 3526.

Moussallem, D., Ferreira, T. C., Zampieri, M., Cavalcanti, M. C., Xexéo, G., Neves, M., & Ngomo, A.-C. N. (2018). RDF2PT: Generating Brazilian Portuguese Texts from RDF Data.

Neves, M., Butzke, D., Schönfelder, G., & Grune, B. (2018). Bf3R at SemEval-2018 Task 7: Evaluating Two Relation Extraction Tools for Finding Semantic Relations in Biomedical Abstracts. Proceedings of The 12th International Workshop on Semantic Evaluation, 816–820.

Neves, M., Jimeno Yepes, A., Névéol, A., Grozea, C., Siu, A., Kittner, M., & Verspoor, K. (2018). Findings of the WMT 2018 Biomedical Translation Shared Task: Evaluation on Medline test sets. Proceedings of the Third Conference on Machine Translation: Shared Task Papers, 324–339.

Piersma, A. H., Burgdorf, T., Louekari, K., Desprez, B., Taalman, R., Landsiedel, R., Barroso, J., Rogiers, V., Eskes, C., Oelgeschläger, M., Whelan, M., Braeuning, A., Vinggaard, A. M., Kienhuis, A., van Benthem, J., & Ezendam, J. (2018). Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicology in Vitro, 50, 62–74.

Rudeck, J., Bert, B., Marx-Stoelting, P., Schönfelder, G., & Vogl, S. (2018). Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes. Toxicology, 404–405, 76–85.

Salatzki, J., Foryst-Ludwig, A., Bentele, K., Blumrich, A., Smeir, E., Ban, Z., Brix, S., Grune, J., Beyhoff, N., Klopfleisch, R., Dunst, S., Surma, M. A., Klose, C., Rothe, M., Heinzel, F. R., Krannich, A., Kershaw, E. E., Beule, D., Schulze, P. C., … Kintscher, U. (2018). Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS Genetics, 14(1), e1007171.

Scheinpflug, J., Pfeiffenberger, M., Damerau, A., Schwarz, F., Textor, M., Lang, A., & Schulze, F. (2018). Journey into Bone Models: A Review. Genes, 9(5).

Schneider, M. R., & Pincelli, C. (2018). The 3R approach to experimental dermatology. Experimental Dermatology, 27(5), 441–442.

Schneider, M. R., & Zouboulis, C. C. (2018). Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. Experimental Dermatology, 27(5), 484–488.

Steinfath, M., Vogl, S., Violet, N., Schwarz, F., Mielke, H., Selhorst, T., Greiner, M., & Schönfelder, G. (2018). Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole. PLOS ONE, 13(9), e0202762.

Stolz, A., Schönfelder, G., & Schneider, M. R. (2018). Endocrine Disruptors: Adverse Health Effects Mediated by EGFR? Trends in Endocrinology and Metabolism: TEM, 29(2), 69–71.


Bert, B., Dörendahl, A., Leich, N., Vietze, J., Steinfath, M., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2017). Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research. PLoS Biology, 15(12), e2003217.

Burgdorf, T., Dunst, S., Ertych, N., Fetz, V., Violet, N., Vogl, S., Schönfelder, G., Schwarz, F., & Oelgeschläger, M. (2017). The AOP Concept: How Novel Technologies Can Support Development of Adverse Outcome Pathways. Applied In Vitro Toxicology, 3(3), 271–277.

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017a). Probleme aus der tierversuchsrechtlichen Praxis: Rechtliche Einordnung der Genotypisierungsmethoden sowie der Zucht immunmodifizierter Tiere. Natur Und Recht, 39(6), 385–392.

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017b). Rechtliche Probleme der Betäubung von Versuchstieren. Natur Und Recht, 39(8), 538–544.

Dahlhoff, M., Gaborit, N., Bultmann, S., Leonhardt, H., Yarden, Y., & Schneider, M. R. (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. The FEBS Journal, 284(19), 3339–3349.

Herold, S., Krämer, D., Violet, N., & King, R. (2017). Rapid process synthesis supported by a unified modular software framework. Engineering in Life Sciences, 17(11), 1202–1214.

Kodzius, R., Schulze, F., Gao, X., & Schneider, M. R. (2017). Organ-on-Chip Technology: Current State and Future Developments. Genes, 8(10).

Schulze, F., Gao, X., Virzonis, D., Damiati, S., Schneider, M. R., & Kodzius, R. (2017). Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips. Genes, 8(10).

Weidner, C., Steinfath, M., Wistorf, E., Oelgeschläger, M., Schneider, M. R., & Schönfelder, G. (2017). A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research. Journal of Visualized Experiments, 126, 55768.


Bert, B., Chmielewska, J., Bergmann, S., Busch, M., Driever, W., Finger?Baier, K., Hößler, J., Köhler, A., Leich, N., Misgeld, T., Nöldner, T., Reiher, A., Schartl, M., Seebach?Sproedt, A., Thumberger, T., Schönfelder, G., & Grune, B. (2016). Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish. The EMBO Journal, 35(11), 1151–1154.

Bert, B., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2016). The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research. EMBO Reports, 17(6), 790–792.

Jungnickel, H., Pund, R., Tentschert, J., Reichardt, P., Laux, P., Harbach, H., & Luch, A. (2016). Time-of-flight secondary ion mass spectrometry (ToF-SIMS)-based analysis and imaging of polyethylene microplastics formation during sea surf simulation. The Science of the Total Environment, 563–564, 261–266.

Kugler, J., Kemler, R., Luch, A., & Oelgeschläger, M. (2016). Editor’s Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line. Toxicological Sciences, 152(2), 382–394.

Kugler, J., Luch, A., & Oelgeschläger, M. (2016). Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro? Trends in Pharmacological Sciences, 37(10), 822–830.

Raasch, M., Rennert, K., Jahn, T., Gärtner, C., Schönfelder, G., Huber, O., Seiler, A. E. M., & Mosig, A. S. (2016). An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex  development. Biomicrofluidics, 10(4), 044102.

Schlechtriem, C., Pucher, J., & Michalski, B. (2016). Dietary burden calculations relating to fish metabolism studies. Journal of the Science of Food and Agriculture, 96(5), 1415–1419.

Weidner, C., Steinfath, M., Opitz, E., Oelgeschläger, M., & Schönfelder, G. (2016). Defining the optimal animal model for translational research using gene set enrichment analysis. EMBO Molecular Medicine, 8(8), 831–838.


Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2015). Der “vernünftige Grund” zur Tötung von überzähligen Tieren. Eine klassische Frage des Tierschutzrechts im Kontext der biomedizinischen Forschung. Natur Und Recht, 37(10), 677–682.

Riebeling, C., Fischer, K., Luch, A., & Seiler, A. E. M. (2015). Classification of reproductive toxicants with diverse mechanisms in the embryonic stem cell test. The Journal of Toxicological Sciences, 40(6), 809–815.

Schönfelder, G. (2015). Laboratory animals: German initiative opens up animal data. Nature, 519(7541), 33.

Schönfelder, G., Grune, B., & Hensel, A. (2015). Animal welfare: Europe’s first “3Rs” governmental centre. Nature, 527(7576), 38.

Smirnova, L., Seiler, A. E. M., & Luch, A. (2015). microRNA Profiling as Tool for Developmental Neurotoxicity Testing (DNT). Current Protocols in Toxicology, 64, 20.9.1-20.9.22.



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