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Replace: Development of new alternative methods for animal testing

In the following you will find current research projects of the Bf3R, which are dedicated to the replacement of animal experiments by alternative methods.


Das Bundesinstitut für Risikobewertung

Teaserbild Smafira

SMAFIRA - Artificial Intelligence for Finding Alternative Methods

A search engine for alternative methods to animal experiments is being developed, based on the freely accessible life science literature database PubMed (Medline). SMAFIRA' stands for 'SMArt Feature based Interactive RAnking'.

Grafik Nachweis hormonaktiver Wirkungen - Teaser

Alternative Methods to Animal Testing for the Detection of Endocrine Disruptors in vitro

Some chemicals and pesticides can affect the endocrine system in humans. Alternative methods can help to identify substances with oestrogenic effects in a high-throughput procedure.

Teaserbild MIA

Software for the Analysis of Imaging Data

For the development of alternative methods to animal testing, imaging microscopic techniques, such as high-throughput imaging, are often used.

Teaser Phänotypisches Screening

Phenotypic screening for assessment of risks from environmental chemicals

We establish and perform phenotypic screening approaches to identify effects of environmental chemicals on cellular morphologies and protein distributions. The results support the toxicological assessment of environmental chemicals without animal testing.

Grafik Einfluss circadianer Regulationssysteme - Teaser

Influence of circadian regulatory systems on in vitro test methods

How do the physiological characteristics of humans and animals behave?  This includes the "internal clock", which as a clock generator regulates such vital processes as body temperature, cardiovascular activity and metabolic activity. To answer this, alternative testing methods are of crucial relevance.

Teaserbild Kanzerohormonaktive Substanzen

Development of an Alternative Method for Testing the Carcinogenic Potential of Hormone-active Substances

Breast cancer is the most common cause of cancer death in women worldwide and, together with colorectal cancer, is one of the two most common types of cancer in Germany. The aim of the project is to use cell culture-based biomedical basic research to develop new in vitro replacement and supplementary methods for breast and colorectal cancer research.

Teaserbild in vitro-Implantationsmodell

Development of an in vitro Implantation Model

The aim of the project is to establish synthetic embryos, so-called embryoids, which represent a physiological and functional in vitro model of mammalian embryogenesis. The model will be used to identify harmful substances. The model is an alternative method to animal testing.

Fadenwurm C. elegans

The nematode C. elegans as an alternative model in toxicology

The nematode Caenorhabditis elegans (C. elegans) has long been used in basic research. Bf3R is investigating the importance of C. elegans as an alternative test system to animal testing in toxicology for the identification of potential health risks of industrial chemicals and pesticides on development and fertility.

Grafik Knochen auf dem Chip - Teaser


Animal models are still indispensable for research into the development of bone and for biomedical studies of bone diseases. Organ chip systems are a possible alternative. 


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