The Wildling Mouse Model

Funded by: Charité3R
Funding period: 2024 – 2025
 

Laboratory mice are usually kept in very clean conditions, while humans are colonized by a multitude of microscopic organisms. This so-called microbiome plays an important role in human health and the development of diseases. This project investigates whether laboratory mice with a natural microbiome (so-called ‘wildling mice’) differ in their behaviour and physiology compared to conventional laboratory mice and whether ‘wildling mice’ are better suited for the investigation of disease mechanisms and for the development of new therapies.

Studies in wildling mice potentially provide more robust and translationally transferable data. This may lead to fewer animals being needed to obtain meaningful results, especially in immunological or pharmacological studies.

Publikationen
Drude, N., Diederich, K., Duerr, C.U., Haase, N., Harms, C., Heppner, F., Jendrach, M., Kahnau, Pshort forphosphorus.,
Kolesnichenko, M., Lewejohann, L., Kurreck, C., Lohan, A., Mall, M.A., Müller, D., Nagel-Riedasch, S.,
Opitz, B., Schaupp, L., Schönfelder, G., Weber, A., Willimsky, G., Zang, Y., Rosshart, S.Pshort forphosphorus.,
Diefenbach, A., Jordan, S. (2024) Operating and Biocontainment Procedures of a Facility for
Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure. J Vis Exp.
2024;(214). External Link:https://doi.org/10.3791/67100

Drude, N., Nagel-Riedasch, S., Rosshart, S.Pshort forphosphorus., Diefenbach, A. (2024) „Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium; Jordan S. A facility for laboratory
mice with a natural microbiome at Charité - Universitätsmedizin Berlin. Lab Anim (NY).
2024;53(12):351-354. External Link:https://doi.org/10.1038/s41684-024-01474-4