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The role of xenoestrogens and GPER receptor for centrosome amplification and chromosomal instability in colorectal cancer cells
Funded by: German Research Foundation (DFG)
Funding period: 2022 - 2025
Aim: Recent work has shown a link between endocrine active substances and an increased risk of colorectal cancer occurrence by influencing cell division processes and stimulating proliferation, migration and metastasis. The underlying mechanisms of this hormone-induced risk potential are still unclear and are the focus of this project.
3R Relevance: Using the latest molecular and cell biological methods and state-of-the-art ultrahigh resolution microscopy, the toxicological mode of action of (xeno-) estrogens will be characterized in vitro. This will not only provide important information on the potential health hazards of endocrine-active substances. Furthermore, the elucidated mechanisms allow the derivation of in vitro methods as a cornerstone for the development of new in vitro replacement and supplementary methods to animal testing in order to identify endocrine disruptors with a carcinogenic risk potential.
